A MID CENTURY RANCH ESTATE IN PALM SPRINGS' MOST STORIED ENCLAVE. In the small, sophisticated enclave of The Mesa, an intimate hillside neighborhood of roughly 258 residences, Hollywood heritage and architectural pedigree meet at the base of the San Jacinto Mountains. This low-density community has long captivated icons such as Clark Gable, Carole Lombard, Natalie Wood, Sonny Bono, and Suzanne Somers, along with visionary figures like King C Gillette. Today, it continues to attract global talent, including renowned Swiss maestro Philippe Jordan, whose home sits just above. Architectural significance defines The Mesa. Modernists Donald Wexler and Hugh Kaptur shaped its distinctive character, while Streamline Moderne pioneers Webster and Wilson created the celebrated "Ship of the Desert", perched directly overhead. Just beneath this landmark lies 290 Lilliana, a luxury mid-century ranch estate with 5 bedrooms, 5.5 baths, 3,870 square feet, and 0.35 acres of private, view-filled grounds, an exceptional scale within this coveted enclave. Set in prized South Palm Springs, away from the wind zone and moments from Downtown Palm Springs, the home enjoys effortless access to boutique shopping, renowned dining, world-class golf, premier tennis clubs, and some of the region's most scenic hiking and biking trails, all while maintaining the rare quiet and privacy that define The Mesa. The home's private, single-level, L-shaped layout integrates indoor and outdoor living, with walls of glass framing panoramic mountain vistas. A sculptural, kidney-shaped pool, raised spa, lush landscaping, and a sunken fire pit create a resort-style environment ideal for both relaxation and sophisticated entertaining. Sunlight fills the open dining and living areas, emphasizing the effortless flow that defines elevated Palm Springs design. A fully equipped guest casita, complete with its own entrance, laundry, bath, and patio, enhances versatility and positions the property as a high-earning luxury short-term rental, especially valuable in The Mesa, which remains under the city's STR cap. For lifestyle buyers and investors alike, the estate could deliver exceptional potential for high-yield vacation rental income. Thoughtful upgrades elevate comfort and efficiency, including modern HVAC systems, refreshed interiors, updated lighting, improved pool equipment, a full sewer conversion for the casita, a new roof, and leased solar panels that help reduce monthly utility costs. These improvements support long-term value while preserving the home's architectural integrity. With its blend of celebrity adjacent prestige, architectural authenticity, resort caliber living, and income-generating flexibility, 290 Lilliana stands among the most compelling offerings in Palm Springs luxury real estate. In a neighborhood where opportunities are scarce, this estate offers a rare chance to own a piece of The Mesa's legendary heritage while securing exceptional modern profitability. YOU OWN THE LAND. WHERE ICONIC ARCHITECTURE, HOLLYWOOD HISTORY, AND CONTEMPORARY INVESTMENT VALUE ALIGN.