1121 E TWIGGS St

Discover an Iconic Commercial Opportunity in the Heart of Tampa’s Channelside District

Position your business at the center of one of Tampa’s most dynamic and rapidly growing neighborhoods—Channelside. Located near Amalie Arena, Water Street, Downtown Tampa, Ybor City, the Port of Tampa, and Harbour Island, this historic four-story brick building offers approximately 21,000 square feet of leasable space (excluding two additional unheated warehouses), blending timeless character with modern commercial upgrades.

The first three floors provide flexible office layouts ideal for professional firms, creative studios, or medical practices. Enter through an elegant marble entryway and experience architectural charm at every turn—heavy 12-foot doors, vinyl flooring on the first floor, carpeted second floor, and original hardwood on the third and fourth floors. Painted brick walls and a winding staircase with black wrought iron railings elevate the interior ambiance, while a functional freight elevator connects all floors for added convenience (available to long-term tenants).

The 3rd and 4th floors are easily accessible via an open internal stairway and combine to offer 10,000 sq ft of luxury office space. Each floor includes two additional designer washrooms and is available at just $24 per sq ft NNN—a rare value in such a prime location.

The 2nd floor, featuring brand new carpeting, is surrounded by five private offices, a break room, and two washrooms. The level also enjoys original brick exterior walls and opens to a mezzanine via the central winding staircase, giving it a distinct, collaborative atmosphere.
Both the 1st and 2nd floors are offered at $26 per sq ft NNN.

The 1st floor includes 3,700 square feet of open showroom or modular office space, perfect for retail, creative, or client-facing operations. This space offers unmatched character with original finishes and easy access to the building’s main entrance.

Atop it all, the top-floor penthouse provides a state-of-the-art executive suite, complete with a commercial-style kitchen, sliding glass barn doors, and a luxurious primary office suite featuring a sunken living room, walk-in shower, and spa-inspired bath. The floor also includes a private exterior door for rooftop access or emergency exit.

Beyond the main building, the property includes two connected warehouses—one measuring 1,824 sq ft and the other 3,300 sq ft—both with dock-high loading access, ideal for logistics, storage, or light industrial use. Rates available upon request.

Additional highlights:

On-site parking for 20+ vehicles

Surrounded by public parking lots and garages

Walkable to major attractions, restaurants, and transit

Located in a qualified opportunity zone for potential tax advantages

Whether you’re expanding your operations or launching a flagship presence, this Channelside gem offers unparalleled visibility, functionality, and cachet. Secure your spot in one of Tampa Bay’s most sought-after commercial corridors, where historic charm meets cutting-edge business potential.