455 Newark Pompton Turnpike presents a unique mixed-use opportunity in the heart of Wayne's highly trafficked retail and service corridor. This highly visible property consists of two units plus additional walk-in basement storage and offers approximately 4,780 SF excluding the basement. The first-floor commercial unit is anchored by the long-established Packanack Animal Hospital, a trusted veterinary practice serving the community for decades. The hospital lease does not include the walk-in basement storage area, offering additional flexibility and value for an owner-user or future tenant. The second-floor unit spans approximately 2,760 SF and is currently configured as a spacious 5-bedroom, 3.5-bath residence featuring a gourmet kitchen, private entrance, chair lift access, and access to a large shared backyard. The layout lends itself well to a live/work setup, staff housing, professional offices, or a variety of other permitted uses. Additional highlights include excellent visibility on Newark Pompton Turnpike, ample on-site parking with potential for expansion, large shared outdoor space, and convenient access to Route 23, Route 46, and Interstate 80. Flexible zoning supports a wide range of commercial and mixed-use possibilities.