Located in the heart of Canandaigua’s bustling North Main Street corridor, 539 North Main Street offers a prime, high-visibility commercial opportunity, with c3 zoning, perfectly suited for a retail flagship, medical office, or service-oriented business. This versatile, 14,624-square-foot building—the former site of a Rite Aid pharmacy—features a substantial 1.8-acre lot complete with a professional brick facade, a reliable flat rubber roof with rooftop HVAC units, and an active security camera system. The interior layout is thoughtfully split, approx 13,000 square feet of expansive retail space and a specialized pharmacy area with locking storage and drive through, plus, a highly functional rear warehouse boasting 21-foot ceilings, an overhead bay door, and loft storage equipped with a large electrical service and convenient rooftop access. Designed for high-volume operations, the property includes a highly valuable 65-space parking lot and a convenient drive-thru. Offered at $1,699,000, this turn-key asset benefits from private ownership rather than corporate bureaucracy, ensuring a streamlined negotiation process and a faster, more predictable closing timeline for savvy investors or business owners. Building is also available for Lease at $12/ SF.  Tax Assessment has been reduced to $1,290,000 for 2026.  This is the opportunity you've been looking for, schedule a private tour today!